Surgery Surgery for these tumors often has to be extensive, with a wide margin of tissue around
the tumor being removed. Sarcomas involving muscles may require removal of the entire affected muscle group.
Bone sarcomas must be removed with a wide margin of apparently normal bone. Amputation can be avoided most of the time, as limb-salvage surgery is often possible in selected patients.
After primary malignant tumors of bone are partially or completely removed, the bone may be reconstructed. This procedure may include bone grafts, but these are not always satisfactory. A more reliable method is custom-made metal bones with artificial joint replacement. Remarkable achievements have made it possible to avoid amputation by substituting a prosthetic bone tailored to the patient. In children, an arm or leg prosthetic bone can be lengthened as the child grows.
Radiation Radiation therapy is used to prevent local recurrences of radiosensitive tumors and may be
given either before or after surgery.
Chemotherapy Several drugs have proven to be effective in treating bone and soft tissue sarcomas.
The dosages required to provide a good chance for cure often produce significant side effects, though.
Effective single agents include doxorubicin , cyclophosphamide , high-dose methotrexate (with leucovorin
